• Amoxil

    Generic Amoxil - is a beta-lactam antibiotic, of penicillin group. Like many products of this category refers to antimicrobial and antiparasitic agents.

    The active substances are amoxicillin trihydrate and clavulanic acid.

    It is more popular in from of tablet, each containing 250 / 500 mg of amoxicillin.

    The excipients are potato starch, low-molecular medical polyvinylpyrrolidone, calcium stearate. The product is known as Amx / Svizmox / Biomox / DisperMox / Larotid / Moxatag / Polymox / Trimox / Wymox. The most trusted generic producers are: Ranbaxy Laboratories and Svizera.

    Amoxicillin - is a semi synthetic aminopenicillin, it acts bactericidal with an optimum diapason of antimicrobial efficiency, it is insensitive to microorganisms forming penicillinase.

    The fact that the clavulanic acid is one of the constituent of this medicine makes amoxil more ben-eficial since the presence of that acid makes this drug more resistant against lactamases.

    That’s how it works

  • Generic Amoxil suppresses the activity of the following microorganisms:
  • - Bacillus anthracis, Enterococcus (faecalis, faecium), Listeria monocytogenes, types of Coryne-bacterium (bacterium that causes diphtheria), Nocardia asteroides (the bacterium that causes no-cardiosis - a disease that affects the lungs, skin, and human brain, causing the formation of ab-scesses in them), Staph. aureus, staphylococci (including Staph. epidermidis), Str. agalactiae, Str. pneumoniae, Str. pyogenes, kinds of Str. viridans;
  • - Clostridia, peptokokki, Peptostreptococcus species;
  • - Bordetella pertussis, types of Brucella, E. coli, Gardnerella vag, Haemophilus influenzae, Helicobacter pylori, Klebsiella, Legionella, Moraxella catarrhalis (Branhamella catarrhalis), N. gonorrhoeae, N. meningitidis, Pasteurella multocida, Proteus mirabilis, Pr.. vulgaris, species of Salmonella, types of Shigella, Vibrio vibroion, Yersinia enterocolitica;
  • - Types of Bacteroides (including Bacteroides fragilis), species of Fusobacterium;
  • - Other bacteria: Borrelia burgdorferi, Chlamydia, Leptospira icterohaemorrhagiae, pale trepone-ma.

  • The remedy is absorbed from the gastrointestinal practically immediately, the Cmax is achieved approximately in 30-45 minutes. The bioavailability of this rx drug may reach 90% during the oral intake. The drug undergoes metabolism in the liver. The medicine spreads out quite actively on epidermis, on fat layers, muscle tissues of the belly cavity, in hepatobiliary system, and as it is de-fined - also in the synovial, peritoneal fluid. The preparation is excreted predominantly in an un-modified form with an urine within the first six hours.

  • - Infectious processes of ENT organs (ears, nose, throat), and lungs;
  • - Infectious processes of the gastrointestinal tract and hepatobiliary system;
  • - Infectious processes of the urinary tract and kidneys;
  • - Infectious processes of the skin and soft tissues;
  • - Infectious processes in bones and joints;
  • - Preventive maintenance of postoperative infectious complications.

  • Side effects:

  • During medical treatment with this drug it may develop the following negative reactions:
  • - Changes in stomach and the intestines - nausea, vomiting, frequent stools, pseudomembranous or hemorrhagic colitis.
  • - Changes in hepatic tests and enzymes, cholestasis with symptoms of jaundice and an inflamma-tion of liver tissues.
  • - On central nervous system - vertigo, headache, convulsions.
  • - Allergic reaction - skin rash, urticaria, rarely severe toxic and allergic reactions in the form of the syndrome of Stevens - Johnson and Lyell syndrome.
  • - reflected on the urinary system - crystalluria, interstitial nephritis.
  • - Venous inflammation localized in place of the undertaken infusion.
  • - Negative deviation in an amount of leukocytes, basophils, neutrophils, eosinophils, platelets and hemolysis of red blood cells .
  • - Negative impact on immune system - allergic vasculitis, serum sickness.
  • - Candidiasis.

  • Contraindications:

  • 1) Individual intolerance to the drug or its components
  • 2) The intolerance to penicillins, cephalosporins, carbapenems.
  • 3) Lactation. Amoxicillin penetrates into the milk that can cause the risk of baby desensitization, so it is necessary to stop breastfeeding during the course of treatment.
  • 4) Take Caution during pregnancy, do not use the drug especially during the first trimester.
  • 5) Not prescribed to pediatric age group up to a year of life.

  • Drugs interaction

  • - In case of simultaneous intake, amoxil and aminoglycoside may inactivate each other.
  • - Tetracyclines, macrolides, chloramphenicol operate in an opposite way towards amoxicillin.
  • - Probenecid, NSAIDs, phenylbutazone, diuretics, allopurinol have a negative impact on excretion of the drug with the urine.
  • - Allopyrinol taken along with Amoxil increases the possibility of allergy development.
  • - Generic Amoxil increases the therapeutic effect of Digoxin.
  • - Simultaneous treatment by acenocoumarol or warfarin along with amoxicillin may cause the risk of bleeding.
  • - Ascorbic acid enhances the absorption of amoxicillin in the intestine.
  • - Harmful effect of methotrexate is enhanced due to simultaneous use of amoxil.
  • Overdose

    In the case of drug overdose some gastrointestinal infringement are observed, also there may be some changes in the ratio of the amount of fluids and electrolytes. Symptomatic treatment with an emphasis on recovery of electrolyte abnormalities. There may occur some symptoms of renal fail-ure associated with impaired renal parenchyma due to crystallization of the drug. Hemodialysis is used in order to eliminate the drug from the bloodstream. In case of anaphylactic shock it is rec-ommended to use adrenaline and steroids as an expected treatment.