• That’s what it is


    Deltasone, also known as Prednisone – is a drug, synthetic analogue of the hormones: cortisone and hydrocortisone, allocated by the adrenal cortex. Its main substance is prednisone. It is 4-5 times more active in comparison to cortisone and 3-4 times more active in comparison to hydrocor-tisone during the oral intake. Unlike cortisone and hydrocortisone, Deltasone does not cause sodi-um and water retention being used in critical volumes and only slightly increases potassium excre-tion. The anti-inflammatory action is provided mainly due to the contribution of cytosolic receptors of corticosteroids. The hormone-receptor complex penetrates into the nucleus of a target skin cells (keratinocytes, fibroblasts, lymphocytes) increases the expression of genes encoding the synthesis of lipomodulins that inhibit phospholipase A2 and reduce the synthesis of products of arachidonic acid metabolism of endoperoxides cyclic, prostaglandins and thromboxane. Deltasone antiprolifer-ative effect is associated with the inhibition of the synthesis of nucleic acids (first of all DNA) in cells of the basal layer of the epidermis and fibroblasts of the dermis. Antiallergic action of the drug is conditioned by diminution in the amount of basophils, by suppression of an immediate synthesis and secretion of biologically active materials.


    That’s how it works

  • 1) It stabilizes cell membranes, including lysosomal.
  • 2) It reduces the output of proteolytic enzymes from lysosomes (braking the phase of alteration and limitation of inflammatory focus).
  • 3) Inhibits phospholipase A2.
  • 4) It violates liberation arachidonic acid and, as a consequence, inhibits the synthesis of PG, hy-droxy acids and leukotrienes.
  • 5) It inhibits the activity of hyaluronidase and reduces the permeability of capillaries (suppression of phase of exudation), fibroblast activity (inhibition of proliferation phase).
  • 6) Has an influence on carbohydrates, proteins, fats and water-salt metabolism.
  • 7) Increases the level of glucose in blood.
  • 8) It contributes into the accumulation of glycogen in the liver, increasing the gluconeogenesis.
  • 9) Activates the processes of kataba.
  • 10) Slows the regeneration.
  • 11) Controls the deamination of amino acids in the liver.
  • 12) Promotes redistribution of adipose tissue.
  • 13) Retains sodium and water in the body.
  • 14) Increases the excretion of potassium.
  • 15) It stimulates the cardiovascular system, increases the tone of the arterioles and myocardial contractility.
  • 16) Excites the central nervous system.
  • 17) It has an antitoxin and immunosuppressive effect.
  • 18) It causes an increase in the secretion of gastric mucosa and gastric acidity.

    Antiallergic properties are conditioned by a breach of the degranulation of mast cells, by the diminution of synthesis of leukotrienes and the suppression of antibody formation, anti-shock ef-fect is demonstrated due to sodium and water retention, increased vascular reaction to exoge-nous and endogenous vasoconstrictor substance and stimulating action on cardiac activity, anti-toxic property is reached by accelerated inactivation of toxic agents in the liver, decreasing penetrability of cell membranes.


  • The drug is easily absorbed when it is administered, the Cmax in plasma is achieved after 1-2 hours. The bioavailability is greater than 90%. Biotransformation exposed, mainly in liver and in kidneys. During an increase in the dose, T1 / 2, total body clearance, volume of distribution and protein binding are also increased.

  • Indications:

  • - Collagen (common name of disease, characterized by diffuse lesions of connective tissue and blood vessels).
  • - Acute and chronic inflammatory joint diseases: gout and psoriatic arthritis, osteoarthritis (including post-traumatic), arthritis, frozen shoulder, ankylosing spondylitis, juvenile arthritis, Still's syndrome in adults, bursitis, nonspecific tenosynovitis, synovitis and epicondylitis , rheumatism, infectious nonspecific polyarthritis (inflammation of multiple joints), rheumatoid carditis, chorea.
  • - Bronchial asthma, asthmatic status.
  • - Acute lymphoblastic leukemia and myeloid (blood malignant tumor arising from hematopoietic bone marrow cells).
  • - Infectious mononucleosis (acute infectious disease, occurring with a high temperature rise, an increase in the palatine glands, liver).
  • - Neurodermatitis (skin disease caused by a violation of the central nervous system).
  • - Eczema (neuro-allergic skin disease, characterized by weeping, itchy inflammation) and other skin diseases.
  • - Addison's disease (decreased adrenal function).
  • - Acute adrenocortical insufficiency.
  • - Hemolytic anemia (decreased hemoglobin content in the blood due to increased decay of eryth-rocytes).
  • - Glomerulonephritis (kidney disease).
  • - Acute pancreatitis (inflammation of the pancreas).
  • - Shock and collapse (sudden drop in blood pressure) in surgical interventions. - To suppress re-jection reactions in transplantation (transplantation from one person to another) of organs and tissues.
  • - Allergic, chronic and atypical conjunctivitis (inflammation of the outer casing eyes).
  • - Blepharitis (inflammation of the edges of the eyelids).
  • - Beryllium, Loeffler's syndrome (not amenable to other therapy.).
  • - Acute and chronic allergic diseases: allergic reactions to medicines and foods, serum sickness, urticaria, allergic rhinitis, angioedema, drug rash, hay fever.
  • - Inflammation of the cornea with intact mucosa.
  • - Acute and chronic inflammation of the anterior segment of the choroid, sclera (opaque portion of the fibrous membrane of the eyeball) and episclera (outer loose layer of the sclera, which are the blood vessels).
  • - Sympathetic eyeball inflammation (inflammation of the front part of the eye vascular membrane in connection with a penetrating wound of the other eye).
  • - Heavy sluggish anterior and posterior uveitis, optic neuritis.
  • - After injuries and surgeries with prolonged irritation of the eyeballs.
  • - Other skin diseases: pemphigus, psoriasis, atopic dermatitis, contact dermatitis (with damage to a large surface of the skin), drug reaction, seborrheic dermatitis, exfoliative dermatitis, toxic epi-dermal necrolysis (Lyell's syndrome), bullous dermatitis herpetiformis, malignant exudative ery-thema (Stevens-Johnson syndrome) .
  • - Primary or secondary adrenocortical insufficiency (including the state after the removal of the adrenal glands), congenital adrenal hyperplasia, kidney disease of autoimmune origin (including acute glomerulonephritis); nephrotic syndrome.
  • - Cerebral edema (including on the background of a brain tumor or associated with surgery, radia-tion therapy, or head injury) after a preliminary parenteral use.
  • - Subacute thyroiditis.
  • - Diseases of the blood: agranulocytosis, panmielopatiya, autoimmune hemolytic anemia, acute myeloid leukemia and lymphoma, Hodgkin's disease, thrombocytopenic purpura, secondary thrombocytopenia in adults, erythroblastopenia (erythrocytic anemia), congenital (erythroid) hy-poplastic anemia
  • - Interstitial lung disease: acute alveolitis, pulmonary fibrosis, sarcoidosis II-III art.
  • - TB meningitis, pulmonary tuberculosis, aspiration pneumonia (in combination with a specific chemotherapy).
  • - Lung cancer (in combination with cytostatics).
  • - Multiple sclerosis.
  • - Gastrointestinal diseases: ulcerative colitis, Crohn's disease, a local enteritis.
  • - Hepatitis, hypoglycemic state.
  • - Hypercalcemia on the background of cancer, nausea and vomiting during cytostatic therapy.
  • - Multiple myeloma.
  • Side effects

    During extended usage there may be: obesity, hirsutism (excessive hair growth in women, mani-festing an increase beard, mustache, etc...), Acne, menstrual disorders, osteoporosis, syndrome Cushing (obesity, accompanied by a decline in sexual function, increased bone fragility due to the enhanced release of adrenocorticotropic pituitary hormone), ulceration of the digestive tract, perfo-ration unrecognized ulcers (occurrence through a defect of the stomach wall or bowel in place sores), hemorrhagic pancreatitis (inflammation of the pancreas, occurring with hemorrhage into her body), hyperglycemia (increased blood sugar levels ), decreased resistance to infection, increased blood clotting, mental disorders.


    Upon termination of the treatment, especially long-term, you may experience a withdrawal syn-drome (sudden worsening of the patient's condition after discontinuation of the drug intake), adrenal insufficiency, acute illness, concerning which the drug prescribed.


    Contraindications

  • 1) Severe forms of hypertension (persistent rise in blood pressure),
  • 2) Severe forms of diabetes and Cushing's disease,
  • 3) Pregnancy
  • 4) The lack of circulation of stage III,
  • 5) Acute endocarditis (inflammation of the inner cavities of the heart)
  • 6) Psychoses,
  • 7) nephritis (kidney inflammation)
  • 8) Osteoporosis
  • 9) Gastric ulcer and duodenal ulcer,
  • 10), recent surgery,
  • 11) Syphilis
  • 12) The active form of tuberculosis,
  • 13) old age.
  • Prednisolone is indicated for diabetes care with or for the treatment of insulin resistance associated with high titers of anti-insulin antibodies. When infectious diseases and tuberculosis medication should be used only in combination with antibiotics or agents for the treatment of tuberculosis.


    During pregnancy the drug can be administered only in extreme cases, because there can be some unpredictable effects on fetal development. It is necessary to abandon breastfeeding during treatment by deltasone.


    The drug is given only under strict medical supervision and only in extreme cases to children of 3 years and older.


    Alcoholic beverages do not affect Deltasone.


    Drug interactions

    If Deltasone is prescribed along with anti-diabetic or anticoagulants, its dosage should be adjusted.


    You should be careful combining deltasone and barbiturates.


    Overdose

    The risk of overdosing increases with prolonged use of prednisolone, especially in large doses.


    Symptoms of overdose: increased blood pressure, peripheral edema, increased side effects of the drug.


    Treatment of acute overdosage: immediate gastric lavage or induction of vomiting, a specific anti-dote is not found.


    Chronic Treatment of overdose: should reduce the dose of the drug.


    Best remedies among generic deltasone:

    Picsolone (PCI Pharma is its manufacturer, the most popular dosage is 5 mg), Omnacortil (made by Macleods, mostly sold in 20 mg dosage), Peesol (produced by Lyon Healthcare, 10 mg dosage is a bestseller).