• Diflucan



    The active ingredient of Diflucan capsules is fluconazole. It has a property to inhibit effectively the synthesis of sterols in fungal cells. Diflucan has demonstrated its effectiveness against Candida spp, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatitidis, Trichophyton spp, Microsporum spp, Coccidioides immitis. It is quickly absorbed, achieving Cmax already in half an hour or in an hour and a half after the intake, the food intake has no influence on drug absorption. The period of half-clearance takes approximately 26-30 hours (that is why the remedy may be taken only one time a day). Fluconazole easily penetrates into the fluids and tissues of the body, its concentration in spinal fluid, saliva, bronchial secretion is nearly the same as in blood plasma and in the stratum corneum the remedy is accumulated in dosages exceeding its concentration in blood. Diflucan doesn’t form active metabolites. Its clearance is provided by kidneys, so it is excreted being practically unchanged.


    Indications

  • - candidiasis, including generalized forms, candidemia, candiduria, candidiasis on the background of immunodeficiency, immunosuppressive therapy, prophylaxis of candidiasis in patients with HIV infection and AIDS;
  • - cryptococcosis, including cryptococcal meningitis cryptococcosis on the background of immunodeficiency, immunosuppressive therapy, prophylaxis of candidiasis in patients with HIV infection and AIDS;
  • - fungal infections of the skin, including chromophytosis;
  • - onychomycosis;
  • - other fungal infections (histoplasmosis, coccidioidomycosis, sporotrichosis, paracoccidioidomycosis).

  • The effective daily dosage is calculated individually depending on the pathology and disease severity. For example, only one intake is needed for the treatment of genital candidiasis. Taking the drug with other pathologies should last until the disappearance of the objective and subjective symptoms. Patients with low immune status (with AIDS, immunosuppression, cancer) usually require maintenance therapy after completion of the primary course of therapy. The duration of therapy is determined individually, depending on the clinical presentation and severity of the disease. For example, the Cryptococcosis course of therapy depends on exact localization of infection and disease severity. In case of cryptococcal meningitis, the treatment continues for at least 6-8 weeks. And the maintenance dose prescribed for patients with AIDS is 0.2 g dosage for a long time. The therapy of generalized forms of candidiasis candidemia starts with a daily dose of 0.4 grams (on the first day), with subsequent transition to the maintenance dose of 0.2 grams. The treat-ment of oropharyngeal candidiasis is carried out within 1-2 weeks at a dose of 0.05-0.1 g. During low immune status, the treatment of oropharyngeal candidiasis may continue for a longer time in order to prevent the relapse, the drug is prescribed in a dose of 0.15 g, once a week. The treatment lasts not less than 2 weeks during oral candidiasis, caused by wearing dentures and Diflucan is prescribed in a daily dosage of 0.05 g, in combination with oral antiseptics. While mucosal candidiasis, except genital candidiasis, the drug is prescribed in a dose of 0.05-0.1 g, the course of therapy lasts during 2-4 weeks.


    In case of chronic genital candidiasis, with frequent exacerbations, it is necessary to take a dose of Diflucan of 0.15 g, once a month for 4-6 months. For the therapy of Candida balanitis, ordinary, the sufficient dose is 0.15 g, taken only once.


    In cases of fungal skin diseases it is recommended to take 0.15 g of fluconazole once per 7 days or 0.05 g daily. The course of treatment lasts 2 - 6 weeks, depending on the location and severity of fungal infection diseases.


    For therapy of tinea versicolor, the prescribed dosage of fluconazole is 0.3 g once a week, this therapy should last for at least 2 weeks. In case of ony-chomycosis, the 15 g of fluconazole is taken once a week, the treatment should continue until the full replacement of the nail by a new one, not infected. For the fingernails this replacement period generally takes up to six months, and 1 year for toenails.


    The therapy of histoplasmosis ordinary lasts 1-1.5 years, the treatment of coccidioidomycosis - from 1 to 2 years, in case of sporotrichosis - from 1 month to 1.5 years and during paracoccidioidomycosis - up to 17 months.


    Side effects

    In most cases, the therapy by Diflucan is conducted without side effects, but in rare cases, there are the following adverse effects:


  • • headache, convulsions, dizziness;
  • • allergic reactions, up to the syndrome of Stevens - Johnson syndrome and Lyell, alopecia;
  • • abdominal pain, changes in liver function tests, dyspepsia, toxic (drug) hepatitis; liver failure, including death;
  • • anaphylaxis, taste alteration, suppression of hematopoiesis.

  • Contraindications

    The remedy is contraindicated for the intake along with terfenadine or cis-apride. The intake of Generic Diflucan during pregnancy is undesirable. During lactation period, it is not suggested to take this medicine, so the therapy should be declined.