• Flagyl

    Flagyl - is a medicament for the treatment of protozoal infections, such as trichomoniasis, leish-maniasis, amoebiasis, and other infections localized mostly in the digestive, respiratory organs, vagina and skin. The drug belongs to the pharmacological group of antimicrobials and antiparasitic agents. It is also know as Metizol / Metric / Metro / Metrocream / Metrogel / Metrogel Vaginal / Nor-itate / Protostat / Vandazole, the most trusted manufactures are Piramal and Vikram pharmaceuti-cal companies. Generic Flagyl is produced in the form of coated tablets. Each contains 200-400 mg of metronidazole as active ingredient + additional components, including wheat starch. There are often 10 - 15 tablets in blisters of a polymer film and aluminum foil, each pack contains the in-struction for use.

    That’s how it works

    Flagyl - is an antimicrobial agent of a broad spectrum of action. Metronidazole - a substance of group of 5-nitro-imidazole. Metronidazole is active against the strains of Bifidobacterium, Bac-teroides fragilis, Bilophilia, Clostridium perfringens, Clostridium difficile, Eubacterium, Peptostrep-tococcus, Fusobacterium, Prophyromonas, Prevotella and Veilonella.

    The drug also slows the development of protozoa, including strains of Trichomonas vaginalis, En-tamoeba histolytica, Giardia intestinalis (Lamblia intestinalis).

    Only the strains of Actinomyces, Propionibacterium acnes and Mobilinkus are not sensitive to the drug. After ingestion metronidazole is rapidly absorbed into the blood. The effect of metronidazole does not dependent on the food intake.


    Flagyl is aimed to treat infections such as:
  • - trichomoniasis with clinical symptoms - both women and men in case of laboratory confirmation of the diagnosis;
  • - asymptomatic trichomoniasis - in women with endocervicitis, cervicitis or cervical erosion;
  • - trichomoniasis in men, as all sexual partners, even without symptoms of the disease should get a prescription on the drug also, in order to prevent reinfestation;
  • - acute intestinal amebiasis (amoebic dysentery) and liver abscess caused by amoebas (including aspiration or draining abscess);
  • - anaerobic bacterial infection, including an infection caused by Bacteroides, including species B. fragilis (B.fragilis, B.distasonis, B. ovatus, B.thetalotaomicron, B. vulgatus), Clostridium spp., Eubacterium spp., Peptococcus niger and Peptostreptococcus;
  • - infections of the skin and appendages caused by Bacteroides (including B. fragilis), Clostridium spp., Peptococcus niger, Peptostreptococcus spp. and Fusobacterium spp;
  • - endometritis, endometritis, tubo-ovarian abscess and other infections of reproductive system caused by bacteria;
  • - bone and joint infections;
  • - CNS infections including meningitis and brain abscess;
  • - lower respiratory tract infections, including pneumonia, empyema and lung abscess;
  • - endocardit caused by Bacteroides (including B. fragilis).

  • Flagyl should be taken orally with plenty of water. The duration of therapy, regimen and dosage of metronidazole should be prescribed by your physician, taking into account the nature of the dis-ease, its location, tolerability and its interaction with the other agents used during the treatment.

    Side effects

    Generic Flagyl rarely leads to the development of negative effects. However, while taking metroni-dazole, in some cases, it may have an influence:

  • - on the nervous system: sensory peripheral neuropathy, headache, ataxia, dizziness, seizures, hallucinations, confusion;
  • - on the digestive system: vomiting, nausea, violations chair, epigastric pain, stomatitis, metallic taste in the mouth, loss of appetite, dryness of the oral mucosa;
  • - on the pancreas and the liver: in rare cases it may develop reversible pancreatitis, decreased liver function and cholestatic hepatitis;
  • - on the blood system: neutropenia, thrombocytopenia, and agranulocytosis;
  • - on allergic reactions of the body: redness and itching of the skin, rash, pustular rash, angioede-ma, anaphylactic shock;
  • - on visual acuity;
  • - on the color of urine.

  • If any of negative reaction occurs, including those that are not mentioned here, you need to stop taking flagyl and consult your doctor.


    Flag is not prescribed to patients intolerant of metronidazole or other components of the drug.

    Flagyl tablets should not be prescribed to patients with hypersensitivity to gluten.

    Flags in pediatric patients should only be used to treat children with a body weight more than 16 kg (over the age of 6 years). Concomitant use of metronidazole with disulfiram or ethanol (alcohol) is strictly contraindicated.

    Caution should be exercised as Flagyl is not recommended to prescribe for patients with severe diseases of the nervous system (due to risk of worsening of neurological status).

    Metronidazole is prescribed with caution to patients with hematological disorders.

    Given the risk of disorders of consciousness, dizziness and loss of visual acuity it is not recom-mended to drive a vehicle or control any unsafe machinery.


    If you take Flagyl with an alcohol it can lead to disulfiram-like reaction (flushing of the skin, vomit-ing, nausea, headache, tachycardia).

    Taking disulfiram and metronidazole concomitantly you may develop delirium and confusion.

    Flagyl may increase plasma concentrations and toxicity of busulifan. Metronidazole may increase plasma concentrations of anticoagulants and enhance the risk of bleeding. If the combination of these drugs is necessary, the prothrombin time should be monitored. Also, the dosage of the anti-coagulant should be adjusted when it's necessary.

    The flag may increase the toxicity of 5-fluorouracil due to the decrease in its clearance.

    During the treatment with metronidazole it is possible to get false-positive result from Nelson's test.


    There has been registered only one case of an overdosage with more than 12 grams of metroni-dazole, the patient noted the development of vomiting, mild ataxia and disorientation. In case of overdose by Flagyl, the standard measures of recovery are recommended: gastric lavage, activat-ed charcoal and symptomatic therapy.