• Synthroid



    Synthroid is one of the best medicines for treating low thyroid activity. Together with other medicines, Synthroid is also prescribed against certain types of thyroid cancer. In those cases when the thyroid gland was completely removed, patients are taking synthroid during the rest of life, as a replacement for a hormone that are normally secreted by thyroid.


    This pharmaceutical product is manufactured in form of tablets, of 25, 50, 75, 100, 125, 150, 175 and 200 mcg of an active ingredient, levothyroxine. The remedy is also known as Eltroxin / Levo-T / Levothroid / Levoxyl / Novothyrox / Unithroid / Thyronorm / Eltroxin / Thyrox. Speaking about the most trusted producers of the drug, these are Abbott / GlaxoSmithKline / Macleods.


    The tablets should be taken orally on an empty stomach, preferably in the morning with a glass of water. The daily dose and dosage are strictly prescribed only by your therapist, depending on the form of the disease, the severity of the course and special indications. It is advised to take medication at one and the same time each day for best results. The drug must be swallowed, but if you have difficulties in swallowing, you can crush the tablet and mix it with water.


    Before taking levothyroxine, you should tell your doctor if you have coronary artery disease, heart disease, anemia, diabetes, clotting problems and adrenal or pituitary gland problems. If you use insulin or any other medicine for diabetes, consult with your doctor before you start taking Synthroid, as it is very important to take into account all the information regarding the other diagnosis and body condition in order to prescribe the most correct dosage and regimen to avoid any side effects.


    That’s how it works

    During ingestion levothyroxine is absorbed almost only in the upper small intestine. Almost 80% of the dose of levothyroxine sodium is absorbed. Any food intake decreases absorption of levothyroxine. Cmax of the active ingredient is observed after 5-6 hours in the blood plasma. It is metabolized primarily in the liver, muscle, brain, kidney. It is excreted from the body with urine and bile. The half-life of the medicine is 6-7 days. Numerous reviews about levothyroxine confirm that the therapeutic effect begins to appear within 3-5 days after first intake. Early hyperplastic diffuse goiter disappears or gets smaller within 3-6 months of taking the drug, during the later stages of the disease a significant reduction of the size of the thyroid gland is observed in more than 30% of cases. It is also necessary to know that generic synthroid in combination therapy with antidepressants and anticoagulants significantly increases the effects of these drugs.


    Indications

  • 1) Toxic diffuse goiter.
  • 2) Euthyroid diffuse goiter.
  • 3) Thyroid cancer.
  • 4) Congenital functional failure of the thyroid gland, which is accompanied by a decrease in mental and physical activity.
  • 5) Hypothyroidism.
  • 6) Prevention of relapse of thyroid nodular malignant tumors after surgery.
  • 7) It is used in treatment of Graves' disease and euthyroid hyperplasia of the thyroid gland.

  • Contraindications

  • 1) thyroid gland hyperfunction of any cause.
  • 2) hypersensitivity to the drug.
  • 3) failure of the adrenal cortex.
  • 4) acute myocardial infarction.
  • 5) during pregnancy, along with thyreostatics as active ingredient levothyroxine sodium reduces their effectiveness, and high-dose thyreostatics can cause the baby congenital hypothyroidism.

  • There are feedbacks on levothyroxine, which evidence that use of the drug can cause the following side effects:


  • - Anxiety, irregular heartbeat, chest pain;
  • - Diarrhea, weight reduction, hypertrichosis, alopecia;
  • - Reduction in adrenal function, tremor, a disorder of renal function;
  • - Allergic reactions: itching, skin rash.

  • With an overdose of the drug can lead to thyrotoxic crisis, which may be delayed a few days after the intake. Symptomatic therapy includes beta-blockers, corticosteroids, plasmapheresis.