• Zithromax



    Generic Zithromax (in form of capsule) is also known as Azit / AzaSite / Zmax / Azivista / Azit / Onazit from popular manufacturers like Cadila / Concept / Elder and Generic Zithromax Dis-persible (in form of dispersible tablet) is also known as Azee DT made by trusty pharmaceutical company Protec.


    The active ingredient of both generic versions of Zithromax - is Azithromycin dihydrate.


    Additional ingredients: sugar, milk, croscarmellose sodium, magnesium stearate.


    Azithromycin represents of a new group of macrolide antibiotics - azalides. It has a wide range of antimicrobial activity, active against a number of both Gram-positive (staphylococci) and Gram-negative (Escherichia and Haemophilus influenzae, Shigella, Salmonella) plague and mycoplasma, legionella, Bacteroides.


    In comparison to erythromycin, it is slower excreted from the body, has a longer-lasting duration of action and is better tolerated. At higher concentrations it provides bactericidal effect. It impedes protein synthesis by ribosomes of microbes.


    That’s how it works

    Azithromycin is stable in acidic medium, lipophilic, rapidly absorbed from the digestive tract. Stored in bactericidal concentrations in the focus of of an infectious inflammation within 5-7 days after the last dose, that allows to use short (3-5 days) courses of treatment. The Cmax is 0,4 mg and is achieved in 2-3 hours when 0.5 g of the product are taken orally. Easily passes through his hema-togenous barriers and cell membranes. The concentration of the drug in tissues is 10-15 times higher than in plasma, and in the source of infection - by 24-34% higher than in healthy tissues and correlates with the degree of inflammation. It is an effective agent against infections caused by in-tracellular germs. Despite the high concentration in phagocytes, azithromycin has no considerable impact on their function.Food intake alters its pharmacokinetics. About 35% of the drug is metabo-lized in liver. It is excreted from plasma within 2 stages: with the bile (60%) and urine (about 5%).


    Indications:

  • - infections of the upper (bacterial pharyngitis, tonsillitis, scarlet fever) and lower (bacterial compli-cations of chronic obstructive pneumonia, interstitial and alveolar pneumonia, bacterial bronchi-tis) respiratory tract;
  • - ENT infections (otitis media, laryngitis, sinusitis);
  • - urogenital infections (uncomplicated urethritis and cervicitis);
  • - infections of skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses, infect-ed dermatoses, chronic migratory erythema stage, Lyme disease);
  • - diseases of the stomach and 12 duodenal ulcer associated with Helicobacter pylori.

  • Side effects

    The drug was well tolerated. But in rare cases there may be nausea, vomiting, abdominal pain, weakness, headache, dizziness, drowsiness, rash, palpitation, angioneurotic edema, eosinophilia. In children - hyperkinesia, nervousness, insomnia, conjunctivitis, excitement.


    Contraindication:

  • - hypersensitivity for macro lipids;
  • - heavy violations of liver functions;
  • - pregnancy;
  • - childish age (before 4 years).

  • This antibiotic is used with caution in patients with the liver or kidney failure, cardiac arrhythmias (ventricular arrhythmias and possible prolongation of the interval QT). After discontinuation of treatment there may appear some hypersensitivity reactions which require specific therapy under medical supervision.


    The elderly and patients with impaired renal function have no need to change the dosage. There is no age limit for the medication usage.


    Overdose

    The cases of drug overdoses were not reported.


    Drugs Interaction

    Antacids containing aluminum or magnesium hydroxide, reduce the absorption and concentration of generic zithromax. It is recommended to take a break for 2 hours between the intake of antacids and zithromax. Drug interactions with theophylline, oral anticoagulants, carbamazepine, phenytoin, digoxin, cyclosporine ergotamine are not observed.